Points to remember here are:
1. High CPR concentration should raise the suspicion for possible infection.
2. CRP, unlike ESR, can change rapidly as condition evolves.
3. Although CPR is very sensitive, it is not very specific. Therefore physical examination of patient is very important.
4. Common uses of CRP are: Infections, Polymyalgia Rheumatica, Rheumatoid Arthritis, Temporal Arteritis, malignancy, vasculitis,
5. Combination of ESR and CRP as well as history and physical examination will enhance the sensitivity and specificity of these tests.
6. Ultimately patients should be treated based on history and physical examination. These tests are not always reliable.
7. Obtaining both ESR and CRP from the beginning and following them serially will help you decide on which one to use for monitoring the disease activity.